Pdf comparison of insulin detemir and insulin glargine for. Comparison of pharmacokinetics and dynamics of the longacting insulin analogs glargine and detemir at steady state in type 1 diabetes a doubleblind, randomized, crossover study francesca. Insulin detemir is a longacting insulin that starts to work several hours after injection and keeps working evenly for 24 hours insulin detemir is used to improve blood sugar control in adults and children with diabetes mellitus insulin detemir. Produced by novo nordisk limited, levemir is the trade name for insulin detemir, a manmade form of insulin that is used as a substitute for the bodys natural insulin in diabetic patients. There is currently no generic alternative for levemir. I nsulin detemir, a longacting form of insulin, works by replacing the insulin that is normally produced by the body and by helping the body to use sugar for energy. This pen is not recommended for use by the blind or visually impaired without the assistance of a person trained in the proper use. Insulin detemir is an acylated insulin analog with threonine removed at position b30, and lysine at position b29 is acylated with a 14carbon myristoyl fatty acid acylation, resulting in delayed. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Levemir is a longacting basal insulin analog manufactured by novo nordisk. Levemir flexpen insulin detemir 100 unitsml solution for.
Levemir insulin detemir is an expensive drug used to treat diabetes mellitus, including diabetes type 1 and diabetes type 2. Change from basal insulin to insulin detemir can be done on a unittounit basis then adjust to achieve glycemic targets. In limited research, it has been shown to cause slightly fewer episodes of minor hypoglycemia and no weight gain in patients. Each prefilled pen contains 300 units of insulin detemir in 3 ml solution for injection. Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in the insulin dose or an adjustment of concomitant antidiabetic treatment. As with all insulin preparations, the time course of action for levemir may vary in different. Levemir insulin detemir is a long lasting insulin that provides consistent, allday blood sugar control with less risk of low blood sugar. Marketed under the brand name levemir, detemir is approved for adults and children with type 1 diabetes and for adults with type 2 diabetes. Other drugs include recently approved symlin pramlintide acetate, as an adjunct treatment in patients who use mealtime insulin therapy and who have failed to achieve desired glucose control despite optimal insulin therapy, and levemir insulin detemir which is indicated for once or twice daily subcutaneous administration in the treatment of. Sections or subsections omitted from the full prescribing information are not listed. With any of the aforementioned insulin types, but more commonly the comparatively shorteracting ones, missing an insulin. Insulin detemir is a longacting recombinant human insulin analog. Common side effects include low blood sugar, allergic reactions, pain at the site of injection, and weight gain.
If using a new vial, pull off the plastic protective cap, but do not remove the rubber stopper 2. Insulin detemir is a longacting insulin that starts to work several hours after injection and keeps working evenly for 24 hours insulin detemir is used to improve blood sugar control in adults and children with diabetes mellitus insulin detemir is used to treat type 2 diabetes in adults. Insulin detemir medicare coverage and copay details goodrx. At this time there was renewed interest in the importance of basal insulin in controlling diabetes and thus preventing or delaying complications, and so technology advanced again. Jul 15, 2006 insulin detemir is suitable as basal insulin in a basalbolus regimen. Insulin detemir side effects, dosage, uses, and more. Insulin detemir should be injected into the fatty tissue under the skin subcutaneously. Levemir insulin detemir injection, solution novo nordiskhighlights of prescribing information these highlights do not include all the information needed to use levemir safely and effectively. Sep 19, 2012 insulin detemir levemir is a soluble longacting human insulin analogue acylated with a 14carbon fatty acid. Treatment with insulin detemir once or twice daily was compared to nph insulin once, twice, or three times per day in an openlabel clinical trial of 310 pregnant women with type 1 diabetes. Insulin detemir is a longacting insulin used to treat diabetes. Acylation of a 14carbon chain fatty acid myristic acid to the lysine residue at position. Learn vocabulary, terms, and more with flashcards, games, and other study tools.
Doses can be easily adjusted to make a customized regimen thats tailored to your bodys needs. Insulin detemir is used to improve blood sugar control in adults and children with diabetes mellitus. This fatty acid modification allows insulin detemir. Levemir insulin detemir dosing, indications, interactions. Apr, 2015 insulin detemir is a prescription medication used to treat type 1 and type 2 diabetes. Treatment with insulin detemir once or twice daily was compared to nph insulin once, twice, or three times per day in an openlabel clinical trial. Apr 26, 2018 the active substance is insulin detemir. Mar 26, 2020 insulin detemir, a longacting insulin, is an alternative for basal insulin therapy in patients with diabetes. Levemir insulin detemir injection 100 unitsml is a manmade insulin that is used to control high blood sugar in adults and children with diabetes mellitus levemir is not meant for use to treat diabetic ketoacidosis. There is clearly a lower withinsubject variability of insulin effect with insulin detemir. Insulin detemir, sold under the brand name levemir among others, is a longacting insulin used to treat both type 1 and type 2 diabetes. Sometimes insulin detemir may be injected twice a day, in the morning before breakfast and in the evening with the evening meal or at bedtime about 12 hours later. Levemir insulin detemir is a manmade form of insulin, a hormone that is produced in the body.
Insulin detemir is a longacting insulin administered by subq injection. An openlabel longitudinal study on the efficacy of. Insulin detemir has been studied in human pregnancy. Learn about side effects, warnings, dosage, and more. Levemir is a manmade insulin used to control high blood sugar in adults and children with diabetes mellitus. Insulin therapy in type 2 diabetes may increase mortality and cancer incidence, but the impact of different types of basal insulins on these endpoints is unclear. If converting from insulin glargine to levemir, the change can be done on a unittounit basis. This material is provided for educational purposes only. Comparison of pharmacokinetics and dynamics of the long. Levemir is not meant for use to treat diabetic ketoacidosis.
Insulin detemir levemir is a longacting insulin analogue indicated for use as basal insulin therapy in patients with type 1 or 2 diabetes mellitus. Insulin glargine detemir insulin glargine detemir recently, insulin degludec ideg, a new, longacting basal insulin preparation, has been made commercially available. Insulin detemir in the treatment of type 1 and type 2 diabetes. Levemir insulin detemir rdna origin dose, indications. Insulin detemir may be given once or twice daily when used as the basal insulin. Insulin detemir levmir for diabetes mellitus steps. Novo nordisk levemir insulin detemir injection, solution. Levemir vial insulin detemir injection 100 unitsml 2 1.
Though generally well tolerated, injection site reactions have been reported in 2% of insulin detemir users. Levemir is produced by a process that includes expression of recombinant dna in saccharomyces cerevisiae followed by chemical modification. Current research shows comparable findings with nph insulin for decreasing hba 1c and. Ideg is reported to have a terminal halflife of approximately 25 hours, which is two times longer than insulin. Jun 12, 2019 insulin detemir is a longacting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. If converting from nph insulin, the change can be done on a unittounit basis. Insulin detemir is used to treat type 2 diabetes in adults. The primary purpose of this study is to determine whether insulin detemir is equivalent to insulin glargine in controlling hyperglycemia for the adult hospitalized patient on a basal. Johns hopkins hospital glucose management committee. Levemir flextouch pen pen is a prefilled disposable pen containing 300 units of u100 levemir insulin detemir rdna origin injection insulin. Jun 15, 2006 a new, longacting insulin analog modified, synthetic form of insulin that acts in the bloodstream for up to 24 hours. Insulin glargine lantus to insulin detemir levemir convert unit per unit. T o p 1 0 l i s t o f s a f e t y t i p s f o r l e v e m i r brought to you by the institute for safe medication practices read this important information before taking.
Insulin detemir versus insulin glargine in the hospital. The fatty acid modification allows insulin detemir to reversibly bind to albumin, thereby providing slow absorption and a prolonged and consistent metabolic effect of up to 24 hours in patients with type 1 or type 2 diabetes mellitus. Objectivethis trial aimed to characterize for the first time the pharmacokinetic profile of insulin detemir, the novel soluble basal insulin analog, in children and adolescents compared with adults. Insulin detemir side effects, uses, dosage, overdose. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Insulin detemir is a longacting, neutral, and soluble insulin analogue with a lower withinsubject variability of fasting plasma glucose levels than isophane insulin human nph insulin. Insulin detemir is an acylated insulin analog with threonine removed at position b30, and lysine at position b29 is acylated with a 14carbon myristoyl fatty acid acylation, resulting in delayed action due to increased binding to albumin. Following subcutaneous injection, insulin detemir binds to albumin via fatty acid chain, thereby providing slow absorption and a prolonged. Levemir definition of levemir by medical dictionary. Allcause and causespecific mortality among users of. Insulin detemir comes as a solution liquid to inject subcutaneously under the skin. The recommended starting dose of levemir in patients with type 2 diabetes who are not currently treated with insulin. Utah medicaid pharmacy and therapeutics committee drug. Insulin detemir differs from human insulin in that the amino acid threonine in position b30 has been omitted, and a c14 fatty acid chain has been attached to the amino acid b29.
Insulin detemir has a molecular formula of c267h402o76n64s6 and a molecular weight of 5916. Once properly stored insulin becomes available, insulin. Mar 24, 2020 levemir insulin detemir injection is a solution for subcutaneous use. Prescription fills for insulin degludec and u300 glargine were very low relative to the usage of other laia products. Levemir vial insulin detemir injection 100 unitsml. Hold the syringe with the needle pointing up in the air and. Dosage of human insulin, which is always expressed in usp units, must be based on results of blood and urine glucose tests and must be carefully individualized to optimal effect. Compared to the traditional nph insulin, the newer, longeracting insulin analogues detemir. Faqs levemir insulin detemir injection 100 unitsml. Levemir is a type of longacting insulin used to treat patients with diabetes by keeping blood sugar levels under control. However, some patients with type 2 diabetes may require more levemir than nph insulin. Insulin detemir levemir is an injectable medication used to treat type 1 and type 2 diabetes.
Two new basal insulin analogues have come to the market. Dailymed levemir insulin detemir injection, solution. Capitals indicate lifethreatening, underlines indicate most frequent. Insulin detemir is a longacting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Insulin detemir is a longacting basal insulin analog, with up to 24 hours duration of action. Insulin is a hormone that works by lowering levels of glucose sugar in the blood. Insulin works by lowering levels of glucose sugar in the blood.
It is usually injected once a day, with the evening meal or at bedtime. Insulin detemir is a soluble longacting human insulin analogue at neutral ph with a unique mechanism of action. Insulin detemir is a new longacting insulin analog. Insulin loses potency when exposed to extreme temperatures which can result in loss of blood glucose control. Insulin detemir may be given once or twice daily when used as the basal insulin component of therapy. Data sources include ibm watson micromedex updated 10 apr 2020, cerner multum updated 6 apr 2020, wolters kluwer updated. If you have questions about this medicine talk to your doctor, pharmacist, or health care provider. Levemir is a clear, colorless, aqueous, neutral sterile solution. When compared to insulin nph, insulin detemir has slower, more prolonged absorption. You can inject from 1 to 80 units in a single injection.
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